• 05Feb

    Arthritis pain management – how to cope with pain?

    Arthritis is a metabolic disease which is characterized by episodes of joint pain. It results due to increased level of urate in blood (hyperuricemia) because of its increased production or reduced excretion in urine. This disease affects usually middle aged men and women after menopause. It may be associated with urate stone formation in kidneys. As the pain associated with arthritis can be severe, it’s crucial to know basic facts about arthritis pain management.

    Arthritis

    Arthritis can be acute or chronic and occurs due to deposition of urate crystals in joints and surrounding connective tissue. Acute arthritis is the most common clinical presentation.  Initially, usually only one joint is affected but later on multiple joints are involved by the inflammatory process. The great toe is usually involved as first. Other joints of the foot, ankle, knees and fingers can also be affected. Painful nodules may appear over these joints. They are called Heberden’s or Bouchard’s nodes and may be the first manifestation of the disease. An acute episode usually starts in the middle of the night, waking the person up. The pain is severe and presents with redness and swelling of the joint. It becomes warm and tender to touch. These attacks usually subside with simple treatment in 5-10 days. Typically, these attacks are precipitated by dietary excess of protein, injury, surgery, alcohol consumption and any serious illness like stroke.


    Diagnosis

    A fine needle is used to aspirate fluid from involved joint or the overlying nodule. Collected substance is examined under a microscope to detect the diagnostic needle shaped urate crystals.

    Uric acid level in the blood is also checked. Though these levels are mostly elevated, they can be low or normal at the time of acute attack because of the uricosuric effect (increasing urine excretion of urate) of inflammatory mediators. So this becomes a limiting factor in the diagnosis of this acute condition. A 24 hour urine collection is assessed to calculate the total uric acid excretion. If this is more than 800 milligram of uric acid per day on a normal diet, it indicates overproduction of uric acid.

    During an acute episode of arthritis it is important to provide pain relief.

    During an acute episode of arthritis it is important to provide pain relief.

    Radiographic imaging in the form of x-rays or CT scanning shows evidence of bone and joint destruction in chronic cases.

    Pain management and treatment

    During an acute episode of arthritis it is most important to provide pain relief. It can be achieved by giving a rest to the inflamed joint by avoiding walking or weight bearing. Use of cold fomentation by ice-pack also helps in reduction of pain and swelling. Avoid consumption of beer and high protein diet during the episode.

    Anti-inflammatory medications like Ibuprofen, indomethacin or diclofenac are useful in mild symptoms. They are usually sufficient in 80-90% of the patients. The symptoms subside in 5-7 days. Oral glucocorticoids like Prednisone can be added. If severe pain persists, then intra-articular injection of steroids (glucocorticoids) can be given. These drugs have a strong anti-inflammatory mechanism of action. That is why they require to be injected by a physician in an aseptic method so as to prevent secondary infection of the involved joint.

    If symptoms still persist, it is advised to consult a physician. A higher level of treatment with the use of colchicine is strictly done under medical supervision.

    Reduction of blood uric acid levels

    To begin with, this can be achieved by reduction of body weight, cutting down intake of purine containing foods (mushrooms, spinach, asparagus, cauliflower, beer, sardines, yeast, legumes, meat extracts), avoiding alcohol and increasing fluid consumption (1.5 to 2 L water per day). Uric acid level should be brought down to 5-6 mg/dl. Urate lowering treatment is started in patients with nodules and chronic arthritis.

    Uricosuric drugs increase excretion of uric acid in urine. However, they are used only in patients with good kidney functions and when their urinary uric acid levels are not already high. The urine volume should be maintained with adequate water intake. Probenecid is an example of uricosuric drug. Another method is to reduce the overproduction of uric acid. Allopurinol acts by this mechanism and it is used especially in patients with kidney stones.

    Arthritis can also be precipitated by certain foods. Being aware of this disease is the best way to reduce the frequency of acute episodes. Severe disease requires an expert management by a physician.

    Anna L.

    It’s all about health!
    I have academic background in drugs related Chemical Technology, as well as extensive professional experience in pharma and medical companies. My main area of interest is everyday life medicine. The goal of my articles is to give people informative answers to the questions that bother them, to dispel doubts and some common misbeliefs and also to inspire everyone to keep healthy lifestyle.

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